Is CI 45380 fungal acne safe?

No, CI 45380 is considered a trigger for fungal acne (Malassezia) as it typically contains lipids or esters that feed the yeast.

Is CI 45380 safe for pregnancy?

Yes, CI 45380 is generally considered safe for use during pregnancy.

Yes, CI 45380 is typically vegan.

Is CI 45380 comedogenic?

Yes, CI 45380 has a comedogenic rating of 3/5, meaning it has a high likelihood of clogging pores.

CI 45380

D&C Red No. 21Eosin

Poor

Red Flag

Pores

3/5

Irritancy

2/5

FA Safe

❌ No

Pregnancy

✅ Safe

Vegan

✅ Yes

Science & Benefits

CI 45380 is a xanthene-based dye known for its 'staining' properties. It is often found in 'lip stains' and long-wear blushes because it reacts with the skin's pH to create a long-lasting tint. However, this same staining mechanism occurs inside the pore. The dye can become trapped within the follicular lining, leading to persistent low-grade irritation and inflammation. This chronic pore-wall irritation is a major trigger for localized acne cosmetica. While it provides beautiful color longevity, it is an intellectual trade-off for those with a high propensity for inflammatory acne and sensitive pores.

Safety Alerts

🍄

Fungal Acne: This ingredient is a lipid/ester that can feed Malassezia yeast. Avoid if you have active FA bumps.